Bio-Sequence Analysis 🧬🔍📑

Biosequence Search 🧬🔍📊 

Biosequence search —encompassing protein sequence search and nucleotide sequence search—is a crucial tool in biotechnology 🧫 and the pharmaceutical industry 💊 for identifying prior art that discloses protein, peptide, DNA, and RNA sequences identical or similar to a query sequence. This type of search is fundamental for ensuring a given biological sequence is novel, supporting the development of new inventions across pharmaceutical, agricultural 🌾, and biotech industries.

The significance of biosequence search is rooted in historical achievements, such as the characterization of insulin protein sequences by Fred Sanger in 1951 🧪📜—a pioneering effort in sequencing long-strand molecules like DNA. This milestone underscored the importance of understanding biological sequences in advancing scientific knowledge and innovation. 💡📈

Types of Sequence Alignment 🧩

• Pairwise Sequence Alignment 🔗
  Compares two sequences to identify regions of similarity, suggesting functional, structural, or evolutionary relationships.
  Tools: BLAST, dot plots

• Multiple Sequence Alignment 🧬📊
  Compares three or more sequences to reveal homology, evolutionary links, or functional similarities.
  Tools: ClustalW, PROBCONS, MUSCLE, MAFFT, T-Coffee